Alkylation of Galactosyl, Mannosyl and Lactosyl Barbiturate
Authors
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G J Clarkson
Chemistry Department, University of Warwick. U.K.
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C A Adah
Chemistry Department, Benue State University, Makurdi
Abstract
The reactions of galactosyl, mannosyl and lactosyl barbiturates with 4-benzyloxybenzyl chloride and į- halo amide with galactose barbiturate were investigated. The products (benzyloxybenzyl-galactosyl barbiturate, benzyloxybenzyl-mannosyl barbiturate, benzyloxybenzyl-lactosyl barbiturate and galactose amide) were characterised by high field nuclear magnetic resonance spectroscopy, mass spectrometry, carbon, hydrogen and nitrogen combustion analyses and further characterised as per- acetate. The alkylation or the barbituric salts proceeds well with the electrophiles and are routes to novel C-glycosyl lectin binders.
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