Effects of Dombeya Buettneri Extracts on Heamapoietic Indices of Wistar Albino Rats
Authors
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Obochi, G. O.
Department of Biochemistry, Benue State University, Makurdi
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Ochalefu, D. O.
Department of Biochemistry, Benue State University, Makurdi
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Amali, E. O. O.
Department of Biochemistry, Benue State University, Makurdi
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Ufaruna, N.
Department of Biochemistry, Benue State University, Makurdi
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Myke Mbata,B.
Department of Chemical Pathology, Benue State University, Makurdi
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Eteng, M. U.
Department of Biochemistry, University of Calabar. Calabar
Abstract
The effects of Dombeya buettneri extracts on electrolyte and heamapoietic indices of wistar albino rats were studied. The results showed that there was a significant increase in red blood cells, white blood cells and hemoglobin, resulting in hemopoiesis and synthesis of hememoiety for hemogloglobin. Thernphytochemical composition showed low phytic acid (trace) which suggests antioxidant activity, enhancing immunocompetence. The LD50 obtained was 2.58mg/kg, suggesting that dosage of Dombeya buettneri below this LD50 is safe. This work suggests that Dombeya buettneri may be useful inrnthe treatment of anemia and may boost immune response, and that administration (dosage) below 2.58mg/kg is safe