• Ojo-Adebayo Eunice Oluwabunmi
  Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria
  




• Akintunde Abimbola Clement
  Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria
  




• Murtala Babatunde Adekunle
  Lagos State University, Physiology Department
  




• Olusan Olusola Adepeju
  Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria
  




• Otunaiya Boluwatife Abisola
  Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria
  




• Oyesola Olusoji Adebusoye
  Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria
  

This study evaluated the chronic administration of Monosodium rnGlutamate to ascertain its effect/impact on blood electrolytes and some rnbiomarkers of the heart, such as lactate dehydrogenase, Troponin and rnCreatine Kinase. Acclimatized Male Sprague-Dawley Rats (n=40) rnwere randomly selected and grouped into four: Control(A), 3% LD50 rn(500mg/kg) (B), 12% LD50 MSG (2000mg/kg) (C) and 24% LD50 rnMSG (4000mg/kg) (D), and were orally administered MSG for 60 rndays. After the experimental period, blood samples were collected rnfrom the animals, activities of the biomarkers of the heart were rnevaluated, lipid peroxidation markers (MDA), oxidative stress marker rnenzymes: SOD, CAT, GSH were also evaluated. During the rnadministration of the extract at various doses, heart enzymes showed rnsignificant decrease (P< 0.05) in rats which received 2000mg/kg and rn4000mg/kg of Monosodium Glutamate when compared with the rnuntreated group. Also, blood electrolytes and antioxidant enzymes rnshowed significant decrease. rnMonosodium Glutamate (MSG) from the result of this study can be rnsaid, when administered from 2000 and 4000mg/kg to lead to rndistortion and dilation of the tissues of the heart/ biomarkers of the rnheart.