• Oyesola AO
  Department Of Physiology, Faculty of Basic Medical sciences, Olabisi Onabanjo University, Nigeria
  




• Odukoya SA
  Department Of Anatomy and Cell Biology, Faculty of Basic Medical sciences Obafemi Awolowo University, Osun State, Nigeria.
  




• Osonuga IO
  Department Of Physiology, Faculty of Basic Medical sciences, Olabisi Onabanjo University, Nigeria.
  




• George ET
  Department Of Physiology, Faculty of Basic Medical sciences, Olabisi Onabanjo University, Nigeria.
  




• Owoeye IIG
  Department Of Physiology, Faculty of Basic Medical sciences, Olabisi Onabanjo University, Nigeria.
  




• James UJ
  Department Of Physiology, Faculty of Basic Medical sciences, Olabisi Onabanjo University, Nigeria.
  

Coffee and vitamin C are staples in our daily lives. This study aimed to investigate the effects of sole and combined usage of coffee and vitamin C on antioxidant enzyme activities and biochemical parameters in selected organs in adult rats. 20 adult male Wistar rats were divided into four groups: Group A (distilled water), Group B (9 mg/kg b/w vit.C), Group C (33.4mg/kg b/w coffee) and Group D (9 mg/kg b/w vit.C + 33.4mg/kg b/w coffee 2 hours after). After 21 days, the rats were sacrificed, and selected organs were excised, weighed and analyzed for antioxidant enzyme activity. Blood samples were collected for biochemical evaluation. Vitamin C intake caused an increase in chloride levels and antioxidant enzyme levels. Coffee intake resulted in the highest increase in most biochemical parameters and antioxidant enzymes studied, and the intake of both gave significant increases in some and decreases in other parameters considered, as compared to the control group. This study indicates that vitamin C consumption causes a decrease while coffee consumption causes significant changes in antioxidant enzymes and biochemical parameters. Their combined administration increased total protein, sodium, chloride, and antioxidant enzymes in the organs of Wistar rats.